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#PKA activation

2 public questions tagged with this topic.

Cell Signaling GPCR Pathways - I

PKA is activated by binding of

cAMP, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Signaling GPCR Pathways - I

PKA activation involves

Inactive protein kinase A is a tetramer of two regulatory and two catalytic subunits. Binding of four molecules of cAMP to the regulatory subunits induces a conformational change that releases the catalytic subunits. Free catalytic subunits then phosphorylate downstream substrates. Reassociation of the holoenzyme occurs when cAMP levels fall, restoring the inactive state.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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