The annotation of a genome sequence is generally stored in which of the following file formats?
In genetics and biotechnology, metabolic engineering and inheritance dictates that exogenous gene introduction and pathway extension enable trait improvement. Therefore GFF is correct as it demonstrates metabolic extension and combinatorial biosynthesis, supported by mechanistic studies and conserved across related systems.
Ref: Hartl and Jones, Genetics: Analysis of Genes and Genomes, 8th Edition, Chapter 7, Mutation and DNA Repair, covers mutation types, DNA repair pathways and genome stability relevant to genetic engineering.