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#peptide isomerization

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Which of the following amino acids is critical in the folding of proteins due to the slow isomerization of the peptide b

The principle of enzyme catalysis and lipid structure explains that substrate affinity, transition state stabilization and phospholipid composition govern function. Hence Proline fits best because it reflects catalytic efficiency and membrane organization, as documented in authoritative sources on biochemistry.

Ref: Berg et al., Biochemistry, 9th Edition, Chapter 13, Metabolism and Bioenergetics, covers glycolysis, citric acid cycle, oxidative phosphorylation and NADH-linked reactions detailing biochemical principles.