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#B cell

3 public questions tagged with this topic.

General Biology and Immunology

Which of the following plays a role in changing the antigen binding site of a B cell after antigenic stimulation?

In immunology, antibody structure dictates that immunoglobulin fold with antiparallel beta-sandwich provides antigen binding. Therefore Somatic hypermutation is correct as it demonstrates immune recognition architecture, supported by mechanistic studies and conserved across related systems.

Ref: Owen, Punt and Stranford, Kuby Immunology, 8th Edition, Chapter 4, Antibody Structure, covers immunoglobulin domains, beta-sheet organization and antigen binding detailing immune recognition.

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Physiology and Immunology

Which one of the following plays a role in changing the antigen binding site of a B cell after antigenic stimulation?

In immunology, antibody structure dictates that immunoglobulin fold with antiparallel beta-sandwich provides antigen binding. Therefore Somatic hypermutation is correct as it demonstrates immune recognition architecture, supported by mechanistic studies and conserved across related systems.

Ref: Janeway et al., Immunobiology, 9th Edition, Chapter 3, Antigen Recognition, discusses immunoglobulin fold, beta-sandwich of antiparallel beta sheets, antibody structure and humoral immunity explaining specificity.

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Genetics

There are five classes of immunoglobulins [Ig]: IgM, IgG, IgD, IgA and IgE. Upon stimulation of B cells through B cell r

The principle of antibody structure explains that immunoglobulin fold with antiparallel beta-sandwich provides antigen binding. Hence IgD fits best because it demonstrates immune recognition architecture, as documented in authoritative sources on immunology.

Ref: Janeway et al., Immunobiology, 9th Edition, Chapter 3, Antigen Recognition, discusses immunoglobulin fold, beta-sandwich of antiparallel beta sheets, antibody structure and humoral immunity explaining specificity.

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