Practice question
Question
There are five classes of immunoglobulins [Ig]: IgM, IgG, IgD, IgA and IgE. Upon stimulation of B cells through B cell receptor and a switch factor, which one of the following Ig classes does NOT switch?
Explanation
The principle of antibody structure explains that immunoglobulin fold with antiparallel beta-sandwich provides antigen binding. Hence IgD fits best because it demonstrates immune recognition architecture, as documented in authoritative sources on immunology.
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