There are five classes of immunoglobulins [Ig]: IgM, IgG, IgD, IgA and IgE. Upon stimulation of B cells through B cell r
The principle of antibody structure explains that immunoglobulin fold with antiparallel beta-sandwich provides antigen binding. Hence IgD fits best because it demonstrates immune recognition architecture, as documented in authoritative sources on immunology.
Ref: Janeway et al., Immunobiology, 9th Edition, Chapter 3, Antigen Recognition, discusses immunoglobulin fold, beta-sandwich of antiparallel beta sheets, antibody structure and humoral immunity explaining specificity.
