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#vaccine‑preventable diseases

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Vaccine is available for all except one of the following pathogens

The principle of antibody structure explains that immunoglobulin fold with antiparallel beta-sandwich provides antigen binding. Hence Helicobacter pylori fits best because it demonstrates immune recognition architecture, as documented in authoritative sources on immunology.

Ref: Owen, Punt and Stranford, Kuby Immunology, 8th Edition, Chapter 4, Antibody Structure, covers immunoglobulin domains, beta-sheet organization and antigen binding detailing immune recognition.