One of the major reasons of the failure of somatic gene therapy protocol can be assigned to
In genetics and biotechnology, metabolic engineering and inheritance dictates that exogenous gene introduction and pathway extension enable trait improvement. Therefore Lack of technique in site specific integration of foreign gene into the chrom... is correct as it demonstrates metabolic extension and combinatorial biosynthesis, supported by mechanistic studies and conserved across
Ref: Griffiths et al., Introduction to Genetic Analysis, 11th Edition, Chapter 5, discusses metabolic pathways, recombinant DNA technology, metabolic extension and Golden Rice as pathway engineering for vitamin A production.
