Which component provides iron transport in serum?
Iron necessity stems from essential cofactor roles in fundamental enzymes: ribonucleotide reductase small subunit R2 contains diferric tyrosyl radical centre essential for reducing ribonucleoside diphosphate to deoxyribonucleotide required for DNA replication and repair, cytochrome c oxidase complex IV contains heme a3 plus copper facilitating electron transport to oxygen, and aconitase iron-sulfur cluster catalyzing tricarboxylic acid cycle. Free ferric iron Fe3+ precipitates as insoluble Fe(OH)3 at neutral pH solubility product extremely low 10^-38, and participates in Fenton reaction Fe2+ p
Ref: Crichton Iron Metabolism 2016 transferrin Fe3+ transport 80 kDa; Alberts MBoC TfR1 clathrin endocytosis ribonucleotide reductase.
