NusG protein couples transcription with
NusG represents conserved transcription factor homologous to eukaryotic Spt5, bridging transcription and translation machineries in bacteria. N-terminal NG domain binds clamp helices of RNA polymerase increasing elongation processivity, while C-terminal KOW domain interacts with ribosomal protein NusE/S10 linking lead ribosome to polymerase during coupled transcription-translation. This physical tether prevents Rho from accessing nascent RNA, suppresses premature termination, and maintains reading frame coupling. NusG also influences DNA repair through interaction with UvrD. Thus primary descr
Ref: Alberts Chapter 6: NusG couples transcription with translation coupling mechanism; Nature 2020 Structure NusG bridging RNAP-ribosome; Lodish Chapter 8 Coupling