What do the Leydig cells secrete?
Androgen correct as per What do the Leydig cells secrete? biology principle.
Ref: NCERT Biology Class XII — Human Reproduction and Reproductive Health
#testosterone
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Which hormone is secreted by the testis?
Testis secretes testosterone from Leydig cells, male secondary sexual characters.
Ref: NCERT Biology Class XII — Human Reproduction and Reproductive Health
Which hormone converts testosterone into dihydrotestosterone (DHT)?
Conversion of testosterone into more potent dihydrotestosterone responsible for external genital masculinization is catalyzed not by hormone but by membrane enzyme steroid 5α-reductase type 2 encoded by SRD5A2 gene. Enzyme localized in genital skin, prostate and hair follicles uses NADPH to reduce testosterone double bond forming DHT. DHT binds androgen receptor with higher affinity and slower dissociation ensuring robust activation of male morphogenetic genes. Confusing hormone with enzyme is common, but catalytic step essential. In provided options intended catalyst for external genitalia vi
Ref: Gilbert, Developmental Biology, 12th ed., Chapter 17: 5α-reductase converts testosterone to DHT.
Leydig cells in mammals produce:
Leydig cells originate from mesenchymal progenitors in interstitial compartment under Desert hedgehog signaling from Sertoli cells and transcription factor Sf1. They express steroidogenic acute regulatory protein and enzymes Cyp11a1, Hsd3b1, Cyp17a1 converting cholesterol to testosterone. Their principal product testosterone secreted in fetal life stabilizes Wolffian ducts differentiating into seminal vesicles, epididymis and vas deferens, supports masculinization of brain and later promotes spermatogenesis. Testosterone also serves as precursor for dihydrotestosterone in external genitalia an
Ref: Gilbert, Developmental Biology, 12th ed., Chapter 17: Leydig cells produce testosterone in fetal testis.
Hormone promoting male genitalia:
Male external genitalia differentiation depends predominantly on dihydrotestosterone acting via androgen receptor in genital tubercle and swellings. While testosterone maintains Wolffian duct derivatives, DHT binding induces conformational change stabilizing androgen receptor dimer that translocates to nucleus and binds androgen response elements regulating morphogenetic genes. DHT drives elongation of tubercle forming penis, canalization of urethra by fusion of urogenital folds, and formation of scrotum from labioscrotal swellings. Loss-of-function of 5α-reductase or receptor results in femin
Ref: Gilbert, Developmental Biology, 12th ed., Chapter 17: DHT drives male external genitalia differentiation.
Enzyme converting testosterone into DHT:
Development of male external genitalia requires local conversion of testosterone secreted by Leydig cells into more active androgen dihydrotestosterone. Reaction catalyzed by microsomal enzyme steroid 5α-reductase type 2 encoded by SRD5A2 gene which uses NADPH to reduce Δ4-5 double bond. DHT exhibits higher affinity for androgen receptor and prolonged receptor-DNA interaction, activating genes for penile growth, urethral closure and scrotal fusion. Deficiency of enzyme causes pseudovaginal perineoscrotal hypospadias despite normal Wolffian ducts, while aromatase converts testosterone to estrad
Ref: Gilbert, Developmental Biology, 12th ed., Chapter 17: 5α-reductase converts testosterone to DHT.
Which of the following statements about testosterone is correct?
Testosterone, secreted by the testes, is responsible for male secondary sexual characteristics such as muscle growth and voice deepening.
Ref: NCERT Class 11 Biology Chapter 19: Chemical Coordination and Integration Mechanism of Hormone Action - Second Messengers
Which hormone is responsible for the development of male secondary sexual characteristics?
Testosterone, secreted by the testes, promotes the development of male secondary sexual characteristics.
Ref: NCERT Class 11 Biology Chapter 19: Chemical Coordination and Integration Gonads - Testis and Ovary Hormones
Which of the following is an incorrect statement about testosterone?
Testosterone is primarily secreted by the testes, not in large amounts by the adrenal cortex.
Ref: NCERT Class 11 Biology Chapter 19: Chemical Coordination and Integration Gonads - Testis and Ovary Hormones
Which hormone plays a crucial role in the process of spermatogenesis?
FSH stimulates sperm production, while testosterone maintains the process of spermatogenesis.
Ref: NCERT Class 11 Biology Chapter 19: Chemical Coordination and Integration Parathyroid Gland and Thymus
