Which repeat is found in telomeric regions?
Repetitive DNA localization reflects functional specialization of chromosome domains. Minisatellites, classified as VNTRs with 10-100 bp units, frequently cluster in subtelomeric and terminal regions, contributing to telomere stability, recombination hotspots and chromosome pairing during meiosis. Macrosatellites also reside at centromeres and heterochromatic blocks. SSRs and STRs, representing microsatellites with 1-6 bp motifs, are interspersed throughout euchromatin rather than enriched at ends. Preferential accumulation of minisatellite arrays near telomeres supports their structural role
Ref: NCERT Biology Class XII Principles on Klenow fill-in labeling, Lehninger Chapter 9 DNA cloning techniques, and Molecular Cloning by Sambrook Chapter 10 documenting end-labeling of cohesive termini.
