The ABC transporter superfamily is involved in:
ABC transporter superfamily represents large gene family with 48 members in humans associated with inherited disorders and drug resistance, present also in bacteria where many function as importers. Core architecture comprises two transmembrane domains typically six helices each forming substrate translocation chamber with diverse selectivity filters, and two nucleotide binding domains located cytoplasmically containing Walker A phosphate binding P-loop, Walker B magnesium coordination hhhhhD, signature C motif LSGGQ characteristic of ABC plus H-loop and Q-loop coordinating ATP. Transport cycl
Ref: Higgins, ABC Transporters Annual Review Cell Biol, Lipophilic Drug Export and MDR Phenotype.
