Super antigens bind to
Mechanistically, antibody structure involves immunoglobulin fold with antiparallel beta-sandwich provides antigen binding. This validates V β domain of TCR and non-polymorphic region of MHC II because it demonstrates immune recognition architecture, a pattern repeatedly demonstrated in immunology research.
Ref: Janeway et al., Immunobiology, 9th Edition, Chapter 3, Antigen Recognition, discusses immunoglobulin fold, beta-sandwich of antiparallel beta sheets, antibody structure and humoral immunity explaining specificity.
