Which of the following is a structural protein providing support to the RBC membrane?
Erythrocyte membrane mechanical resilience originates from spectrin ankyrin network linkage. Ankyrin-1 large adaptor of approximately two hundred six kilodaltons comprises three domains: N-terminal membrane binding domain of twenty four ankyrin repeats each thirty three residues forming elongated solenoid that binds high affinity site on Band 3 cytoplasmic domain residues one seventy five to one eighty five and other integral proteins sodium-potassium ATPase, sodium channel Nav1.5, cell adhesion molecule L1; central spectrin binding domain of about one hundred residues binding beta spectrin re
Ref: Bennett and Healy, Membrane Protein Complexes and Ankyrin Function, Annu Rev Cell Dev Biol.
