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#stem cell classification

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Stem Cell -ll

Spermatogonial stem cells are classified as:

Spermatogonial stem cells reside along basement membrane of seminiferous tubules within specialized niche maintained by Sertoli cells producing glial-derived neurotrophic factor GDNF and fibroblast growth factor FGF2. In steady-state spermatogenesis they undergo self-renewing divisions to maintain pool and simultaneously produce differentiating spermatogonia that ultimately yield haploid spermatozoa through meiosis. Although capable of long-term self-renewal like other adult stem cells, lineage tracing demonstrates in vivo they generate only sperm lineage, and during prolonged culture can rega

Ref: De Rooij & Russell, Reproduction 2000; Kanatsu-Shinohara, Cell 2003: Spermatogonial stem cells unipotent.

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Stem Cell -lll

Hematopoietic stem cells (HSCs) are classified as:

Hematopoietic stem cells isolated from bone marrow as lineage negative Sca1 positive cKit positive population sustain all blood lineages including myeloid granulocytes, monocytes, erythroid cells and lymphoid B and T cells but not extraembryonic or non-hematopoietic tissues, defining multipotency within hematopoietic system. They self-renew long-term repopulating irradiated recipients and serial transplantation, generate committed progenitors common myeloid progenitor and common lymphoid progenitor via transcription factors GATA1, PU.1, Ikaros. Totipotent generates entire organism including pl

Ref: Orkin and Zon, Hematopoiesis, Chapter 2: Multipotent Hematopoietic Stem Cells Classification.

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