The microtubule-severing enzyme activated during mitosis is:
During mitosis interphase long stable microtubules must be extensively remodeled into highly dynamic spindle capable of search and capture chromosome alignment and segregation. Two coordinated regulatory shifts occur: dramatic phosphorylation of stabilizing MAPs such as MAP2 MAP4 and tau by CDK1 Aurora B and other mitotic kinases reduces their affinity several fold detaching them from lattice exposing filament to remodeling enzymes and increasing turnover; concurrently microtubule severing AAA ATPases katanin spastin and fidgetin activated via phosphorylation recruitment and release from seque
Ref: McNally & Roll-Mecak, J Cell Biol 2018 – Mitosis severing enzymes including katanin regulation and MAP2 phosphorylation.
