Which of the following regulates vesicle docking before fusion?
Before trans-SNARE zippering drives bilayer merger vesicles must be captured near correct target ensuring compartment identity maintained despite promiscuous SNAREs. Rab GTPases provide master specificity for docking stage. Active GTP-bound form on vesicle or target exposes switch regions binding effectors. Examples: Rab1-GTP recruits p115 and GM130 at ER-to-Golgi interface forming extended coiled-coil tether over 200 nm, Rab5-GTP recruits EEA1 and Rabenosyn-5 containing FYVE domains binding PI3P plus alpha helical tether, Rab6 recruits GCC185, Rab7 recruits HOPS complex VPS11-18-39-41. This p
Ref: Alberts et al., MBC: Rab GTPases regulate vesicle docking before SNARE-mediated fusion.
