Skip to content
Login Register

#self-renewal

2 public questions tagged with this topic.

Stem Cell -ll

Which of the following is NOT a function of stem cells?

Stem cells actively participate in tissue development, continuous renewal, repair after injury, and homeostatic maintenance through balanced self-renewal and differentiation, secreting trophic and immunomodulatory factors that modulate niche environment and immune response. Apoptosis is programmed cell death executed by intrinsic and extrinsic caspase cascade leading to orderly elimination of damaged, redundant, or infected cells, characterized by membrane blebbing, chromatin condensation, DNA fragmentation, and phagocytic clearance without inflammation. It is not a constructive synthetic func

Ref: Fuchs & Blau, Cell Stem Cell 2020; Gilbert, Chapter 6: Stem cell functions regeneration versus apoptosis distinction.

View Details
Stem Cell -ll

Which of the following is NOT a property of stem cells?

Canonical stem cell properties include prolonged self-renewal through cell cycle regulators such as telomerase, Bmi1 Polycomb protein, and p27 control, capacity to differentiate into multiple mature types under niche instructions, and dependence on niche signals for maintenance of undifferentiated state. Transit-amplifying and terminal differentiation pathways ensure progeny exit cell cycle and perform specialized functions such as absorption or contraction. If a cell terminally differentiated upon each division, it would lose self-renewal and rapidly exhaust the pool, contradicting lifelong r

Ref: Watt & Hogan, Science 2000; Gilbert, Chapter 6: Stem cell properties self-renewal versus terminal differentiation.

View Details