Which of the following is not a function of the rough ER?
Rough ER domains studded with polysomes perform cotranslational folding and modification of secretory and membrane proteins. As nascent chain emerges into lumen via Sec61, protein disulfide isomerase catalyzes oxidative formation of disulfide bonds favored by high ratio of oxidized to reduced glutathione, peptidyl-prolyl isomerases accelerate isomerization, and oligosaccharyltransferase attaches N-linked glycans to asparagine within N-X-S/T sequons. Chaperones BiP and calnexin monitor folding, retaining immature proteins preventing aggregation. N-linked glycosylation and disulfide formation se
Ref: Alberts Ch 12; rough ER folding disulfide N-glycosylation BiP calnexin; lipid synthesis smooth ER.
