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#RNA polymerase III

2 public questions tagged with this topic.

Cell Biology and Molecular Biology

α-Amanitin is a fungal toxin which inhibits eukaryotic RNA polymerases. The three eukaryotic RNA polymerases show differ

In molecular biology, nucleic acid structure and recombination dictates that hairpin formation, Holliday junction resolution and translation control ensure fidelity. Therefore RNA POL II > RNA POL III > RNA POL I is correct as it matches molecular mechanisms of gene expression, supported by mechanistic studies and conserved across related

Ref: Alberts et al., Molecular Biology of the Cell, 6th Edition, Chapter 5, DNA Replication and Repair, discusses Holliday junction formation during homologous recombination and replication fork dynamics ensuring genome duplication and stability.

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Transcription in Eukaryotes

RNA polymerase III transcribes

RNA polymerase III transcribes short noncoding RNAs shorter than three hundred nucleotides required for protein synthesis and RNA processing. Products include all transfer RNAs, 5S ribosomal RNA, U6 small nuclear RNA involved in splicing, 7SL RNA of signal recognition particle, 7SK RNA regulating P-TEFb, and Alu short interspersed elements. Transcription uses internal promoter elements type one with intermediate element for 5S bound by TFIIIA, and type two with A and B boxes for tRNA bound by TFIIIC. Pol III sensitivity to alpha-amanitin is intermediate at ten micrograms per milliliter.

Ref: Alberts et al., Molecular Biology of the Cell, 7th ed., Chapter 6: Pol III transcribes tRNA and 5S rRNA; Lodish 9th ed., Small RNA transcription

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