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Ribosomes are not membrane-bound organelles; they are freely floating in the cytoplasm or attached to the rough ER.
Ref: NCERT Class 12 Biology Chapter 5: Molecular Basis of Inheritance Human Genome Project and DNA Fingerprinting
Ribosome exhibits blind acceptance phenomenon because it checks codon-anticodon pairing but not amino acid identity attached to tRNA. Aminoacyl-tRNA synthetases occasionally mischarge, producing for example valine attached to tRNAIle. When such misacylated species enters A site with correct anticodon matching codon, decoding center verifies RNA duplex only and permits peptide incorporation, leading to misincorporated amino acid. This highlights division of labor: synthetases ensure chemical fidelity while ribosome ensures pairing fidelity. Biotechnology exploits blind acceptance to incorporate
Ref: Alberts et al., Molecular Biology of the Cell, 7th ed., Chapter 7, Ribosome blind acceptance of mischarged tRNAs
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