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#Rho protein

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Rho protein is best described as

Rho protein functions as homohexameric motor translocating along nascent RNA toward polymerase, coupling ATP hydrolysis to RNA displacement. Structural analysis reveals each subunit contains N-terminal oligonucleotide-binding domain forming primary C-rich rut binding site and C-terminal RecA-like ATPase domain providing RNA-dependent ATPase and 5' to 3' helicase activities. Mechanism resembles ring helicase threading RNA through central pore. Rather than simple endonuclease or ligase, Rho acts mechanical translocase unwinding RNA-DNA hybrid within elongation complex. Inhibitor bicyclomycin tar

Ref: Lodish Molecular Cell Biology Chapter 8: Rho RNA-dependent ATPase helicase structure function; Alberts Chapter 6: Rho hexameric translocase model