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#receptor tyrosine kinase

4 public questions tagged with this topic.

Paracrine Factor

Which of the following is an example of a receptor tyrosine kinase (RTK) ligand?

Receptor Tyrosine Kinase ligands are typically soluble growth factors like EGF, FGF, PDGF, VEGF, Insulin, HGF forming dimers bridging receptors. Fibroblast Growth Factor binds FGFR1-4 extracellular IgII-III domains causing dimerization, trans-autophosphorylation of activation loop tyrosines Y653/654 activating Ras-MAPK, PI3K-AKT, PLCγ signaling driving proliferation, survival, chemotaxis. This mitogenic RTK signaling contrasts Hedgehog which signals via Patched-Smoothened GPCR-like seven-pass mechanism not involving tyrosine kinase, Wnt via Frizzled-LRP beta-catenin, and Delta via Notch proteo

Ref: Gilbert, Developmental Biology, 12th ed., Chapter 4: FGF as prototypic receptor tyrosine kinase ligand for induction.

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Cell Signaling ELR Pathways - I

Cross-talk between JAK–STAT and RTK pathways allows activation of

multiple downstream branches, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Signaling ELR Pathways - I

Constitutively active RTK mutations generally cause

uncontrolled proliferation, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Cell Signaling ELR Pathways - I

Sevenless (Sev) receptor in Drosophila is an example of

RTK, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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