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Fibrous proteins have elongated structures and are insoluble in water. Collagen, found in connective tissues, is an example.
Ref: NCERT Class 12 Chemistry > Chapter 14: Biomolecules > Topic: Proteins - Structure, Classification and Denaturation
Globular proteins are spherical and water-soluble. Insulin is an example, unlike fibrous proteins like keratin.
Ref: NCERT Class 12 Chemistry > Chapter 14: Biomolecules > Topic: Proteins - Structure, Classification and Denaturation
Membrane protein classification by lipid modification clarifies attachment without transmembrane span. Ras GTPases undergo prenylation by farnesyltransferase recognizing C-terminal CAAX motif, subsequent RCE1 proteolysis, ICMT methylation, and for N-Ras and H-Ras additional Golgi palmitoylation by DHHC enzymes driving plasma membrane targeting and partitioning into ordered domains for MAPK signaling and transformation. Src family kinases c-Src, Fyn, Lck, Yes undergo cotranslational N-myristoylation at glycine two plus reversible S-palmitoylation for stable inner leaflet association recruiting
Ref: Pollard and Earnshaw, Cell Biology, 3rd ed., Chapter 17, Actin Filaments and Lipid-Anchored Proteins.
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