Subunit vaccines contain:
Subunit vaccines avoid using whole infectious organism replication-competent incorporating only highly purified antigenic components capable eliciting protective immunity without risk producing disease immunocompromised pregnant elderly. Antigens include recombinant proteins hepatitis B surface antigen HBsAg 226 aa small S self-assembling 22 nm VLPs Saccharomyces cerevisiae Hansenula after methanol induction AOX1 promoter purification density gradient acellular pertussis components pertussis toxoid chemically toxoided formaldehyde hydrogen peroxide inactivation removing ADP-ribosylating activi
Ref: Plotkin Vaccines Subunit Concept Hepatitis B HBsAg Yeast; WHO Subunit Vaccine Development Production Guidelines 2022; Janeway Immunology Subunit vs Whole Organism Chapter 12.
