A limitation of polysaccharide vaccines is that they:
Polysaccharide vaccines face intrinsic limitation that they induce serotype specific immunity due to structural diversity of capsular polysaccharides among bacterial strains. For instance Streptococcus pneumoniae possesses greater than 90 serotypes each with distinct repeating unit composition differences in sugar sequence, glycosidic linkage alpha 1-3 vs beta 1-4, side chains and O-acetylation patterns dictating distinct antigenic epitopes. Antib Antibodies raised against polysaccharide of serotype 14 recognizing beta-D-galactose 1-4 linkage do not cross react with serotype 19F containing glu
Ref: Geno Immun Rev Polysaccharide serotype specific; Plotkin Pneumococcal limitation serotype; WHO.
