In centrifugation, if the angular speed is constant, the time required for pelleting cells in a rotor of larger size
Mechanistically, cellular compartmentalization and cell cycle involves SNARE-mediated trafficking, Hayflick limit, P53 and cyclin regulation control proliferation. This validates will be shorter because it aligns with membrane trafficking and cell cycle control, a pattern repeatedly demonstrated in cell biology research.
Ref: Alberts et al., Molecular Biology of the Cell, 6th Edition, Chapter 10, Membrane Structure and Transport, discusses SNARE proteins, vesicle trafficking, ER, Golgi, endosome membranes and selective transport providing compartmentalization foundation.
