Which of the following is a characteristic of P-class ATPases?
ATP-driven pumps belong to several mechanistically distinct families distinguished by architecture, subunit composition and mechanism of coupling hydrolysis to transport. P-type family named because first discovered intermediate was phosphorylated enzyme, now understood to include Na+/K+ ATPase maintaining sodium potassium gradients, sarcoplasmic reticulum Ca2+ ATPase SERCA sequestering calcium, plasma membrane Ca2+ ATPase PMCA extruding calcium, gastric H+/K+ ATPase acidifying stomach and heavy metal copper and manganese pumps ATP7A ATP7B. Core mechanism involves conserved aspartate within DK
Ref: Palmgren and Nissen, P-Type ATPases Annual Review Biophys, Mechanism: Phosphorylated Intermediate Formation.
