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#optic cup

2 public questions tagged with this topic.

Eye Lens Induction -l

Which of the following describes the optic cup?

Following contact with lens placode, distal optic vesicle undergoes invagination to form double-walled optic cup. Signaling from surface ectoderm and lens, including BMP, FGF and Wnt antagonists, patterns cup: inner layer facing lens becomes neural retina expressing Vsx2 and Rx, while outer layer becomes retinal pigment epithelium expressing Mitf and Otx2. The rim contributes to ciliary body and iris. This bilayer originates entirely from neuroectoderm, not surface ectoderm or mesoderm, and later gives rise to photoreceptors, neurons and pigment cells essential for vision and structural suppor

Ref: Gilbert, Developmental Biology, 12th ed., Chapter 16: Optic cup differentiation into neural retina and RPE.

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Eye Lens Induction -ll

Which of the following describes the optic cup?

Optic cup is bilayered invaginated structure derived from optic vesicle neuroectoderm following contact with lens placode. Distal portion contacting lens becomes inner layer neural retina expressing Chx10 and Rx specifying photoreceptors and interneurons, outer layer becomes retinal pigmented epithelium expressing Mitf and Otx2 producing melanin and supporting retina. Optic cup does not form cornea which originates from surface ectoderm and periocular mesenchyme, is not mesodermal, nor surface ectodermal. Classic reciprocal induction ensures coordinated invagination of both lens vesicle and op

Ref: Gilbert, Developmental Biology, 12th ed., Chapter 12: Optic cup differentiation – neural retina and RPE formation.

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