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#nuclear lamina

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Cell Organelles

The nuclear lamina is composed of:

Meshwork underlying inner nuclear membrane known as nuclear lamina provides mechanical strength preventing envelope rupture under cytoskeletal tension transmitted via LINC complex and organizes chromatin positioning. It consists of intermediate filament proteins lamins subclassified into B-type encoded by LMNB1 and LMNB2 constitutively farnesylated for membrane anchorage, and A-type encoded by LMNA via alternative splicing producing lamin A including farnesylated precursor processed to mature form and lamin C lacking farnesylation, expressed after differentiation. Lamins assemble via parallel

Ref: Burke Annu Rev Cell Dev Biol; lamins A/B/C type V IF, farnesylation, lattice under inner membrane.

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Cytoskeleton

What is the function of the nuclear lamina?

Interphase nucleus experiences mechanical stresses from cytoskeletal pulling forces migration through constricted spaces and chromatin dynamics requiring reinforcement beyond lipid bilayer envelope alone. Nuclear lamina provides mechanical support as dense meshwork 10 to 20 nm thick apposed to inner nuclear membrane beneath lamina associated chromatin domains. Composed of A type lamins lamin A and C splice isoforms and B type lamins B1 B2 type V intermediate filament proteins forming coiled coil dimers assembling head to tail polymers into orthogonal filaments crosslinked into sheet. Mesh conf

Ref: Dechat et al., Genes Dev 2008 – Nuclear lamina provides mechanical support to nucleus function.

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