Which of the following is an intermediate filament protein found in neurons?
Neuronal cytoskeleton requires robust ten nanometer filaments to stabilize long processes subjected to bending and tension during growth and circuitry formation. Neurofilament proteins comprise heteropolymers of NF-L light sixty one kDa, NF-M medium one hundred two kDa and NF-H heavy one hundred twelve kDa subunits, each with conserved central rod domain forming coiled-coil dimers and variable C-terminal tails enriched in Lys-Ser-Pro repeats heavily phosphorylated to extend as sidearms regulating interfilament spacing and axonal diameter, which directly influences conduction velocity. Alpha-in
Ref: Liem J Cell Biol; neurofilaments NF-L/M/H heteropolymers regulate axon caliber, neuron-specific IF.
