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#neural retina

2 public questions tagged with this topic.

Eye Lens Induction -l

Which factor is required for the neural retina formation?

Neural retina originates from inner layer of optic cup and requires sustained Pax6 together with Rx, Otx2, Mitf repression and FGF signals. Pax6 directly activates neural retina determinants Vsx2, Six6 and Atoh7, promoting retinal progenitor proliferation and later genesis of ganglion and photoreceptor cells. Conditional deletion of Pax6 in optic vesicle after lens induction results in transdifferentiation toward retinal pigment epithelium expressing Mitf, loss of neural retina lamination. While Sox2, Otx2 and L-Maf function in lens or RPE, Pax6 remains indispensable for neural retina identity maintenance and differentiation into functional light-sensing tissue.

Ref: Baumer et al. Development 2003; Gilbert Chapter 16: Pax6 required for neural retina formation and maintenance.

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Eye Lens Induction -ll

Which factor is required for neural retina formation?

Neural retina formation from inner layer of optic cup requires sustained Pax6 expression cooperating with Rx, Chx10, and Sox2 transcription factors. Pax6 maintains retinal progenitor multipotency, activates proneural genes Atoh7 and Neurod1 for ganglion and amacrine differentiation, and represses retinal pigmented epithelium fate via Mitf suppression. Sox2 also expressed but alone insufficient, Otx2 specifies RPE, L-Maf drives lens crystallins. Pax6 conditional deletion in optic cup converts presumptive neural retina into pigmented epithelium and abolishes retinogenesis, demonstrating essential role in neural retinal specification, differentiation, and maintenance of progenitor pool.

Ref: Gilbert, Developmental Biology, 12th ed., Chapter 12: Neural retina formation – Pax6 requirement and Mitf repression.

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