The similarities between mitogenic stimulation by EGF and depolarization of the membrane of skeletal muscle cell by acet
In cell biology, cellular compartmentalization and cell cycle dictates that SNARE-mediated trafficking, Hayflick limit, P53 and cyclin regulation control proliferation. Therefore Ligand mediated coformational change in the receptor of responding cell is correct as it aligns with membrane trafficking and cell cycle control, supported by mechanistic studies and conserved across
Ref: Alberts et al., Molecular Biology of the Cell, 6th Edition, Chapter 10, Membrane Structure and Transport, discusses SNARE proteins, vesicle trafficking, ER, Golgi, endosome membranes and selective transport providing compartmentalization foundation.
