Which protein is responsible for mitochondrial fission?
Mitochondrial network dynamics depend on opposing fusion elongating networks facilitating complementation and fission fragmenting for segregation and mitophagy. Fusion of outer membranes driven by mitofusins Mfn1 and Mfn2 homotypic and heterotypic GTPases anchored outer membrane forming trans dimers tethering via HR2 domains and GTP hydrolysis merging membranes; inner membrane fusion by OPA1 dynamin-like GTPase regulated by proteolytic processing L and S forms. Fission central executor is Drp1 encoded DNM1L, eighty kDa dynamin-related GTPase cytosolic, recruited by receptors Fis1, Mff, MiD49,
Ref: van der Bliek Cell; Drp1 DNM1L GTPase Mff Fis1 MiD49/51 fission, Mfn1/2 OPA1 fusion.
