The MDR1 (ABCB1) transporter is responsible for:
MDR1 officially ABCB1, also called P-glycoprotein P-gp, is a 1280 amino acid 170 kDa glycosylated plasma membrane exporter noted for conferring resistance to colchicine and doxorubicin in selection experiments. Tissue distribution includes apical brush border of small intestinal enterocytes limiting drug absorption, canalicular membrane of hepatocytes promoting biliary excretion, luminal membrane of proximal renal tubule mediating urinary elimination, endothelial cells of blood-brain barrier restricting central entry, and placental syncytiotrophoblast protecting fetus. Substrates are typically
Ref: Sharom, Pharmacogenomics 2008, P-glycoprotein; Alberts, 7th ed., Chapter 11 MDR transporters.
