Which type of lipid interaction is disrupted by methyl-β-cyclodextrin?
Lipid raft integrity pharmacologically perturbed using methyl beta cyclodextrin torus shaped oligosaccharide seven glucose units hydrophobic interior cavity zero point eight nanometer diameter fitting sterol. Cavity fits cholesterol high affinity one to two stoichiometry extracting sterol membrane into soluble inclusion complex without hydrolyzing phospholipids at low concentrations below ten millimolar preserving phospholipid mass. Removal dismantles cholesterol sphingolipid condensed complexes driven van der Waals packing hydrogen bonding amide hydroxyl interactions transforming liquid order
Ref: Zidovetzki & Levitan, Biochim Biophys Acta 2007, Cyclodextrin cholesterol sphingolipid raft disruption mechanism and reversibility.
