Which is not a function of lipid-linked proteins?
Functional spectrum of lipid-linked proteins encompasses dynamic localization and signal integration far beyond simple tethering. N-myristoylated and palmitoylated kinases like Src family and non-receptor tyrosine kinases concentrate at inner leaflet raft domains upon growth factor stimulation scaffolding MAPK, PI3K pathways regulating proliferation and cytoskeletal remodeling. Small GTPases Ras Rab and Arf require prenylation plus secondary palmitoylation for vesicular transport from endoplasmic reticulum through Golgi to plasma membrane controlling vesicle budding and fusion. GPI anchors of
Ref: Bhatnagar and Gordon, Understanding Protein Lipidation, J Cell Biol Reviews.
