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#heart regeneration

2 public questions tagged with this topic.

Regeneration -l

Which type of regeneration is seen in hydra and zebrafish heart regeneration?

Morphallaxis defined by Morgan involves repatterning existing tissues without significant proliferation or blastema formation, producing smaller proportionate animal. Hydra regenerates via morphallaxis when body column fragment reorganizes without growth to reform hypostome and basal disc. Zebrafish heart regeneration includes border zone cardiomyocyte shape change and limited migration partially resembling morphallactic reorganization before proliferative phase, hence classified in question as morphallaxis emphasizing remodeling over blastema growth. Epimorphosis requires blastema such as sal

Ref: Gilbert, Developmental Biology, 12th ed., Chapter 19: Morphallaxis in Hydra and zebrafish heart remodeling.

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Regeneration -l

Which organism is commonly used to study heart, retina, and fin regeneration?

Zebrafish has become favored vertebrate model because it reproducibly regenerates amputated caudal fin with patterned bony rays, resected myocardium via cardiomyocyte dedifferentiation and proliferation without permanent scar, adult retina after photoreceptor destruction via Müller glia reprogramming, spinal cord axons, and sensory hair cells. Advantages include external fertilization, optical transparency, genetic screens, and conserved signaling pathways Wnt, FGF, Notch, Hedgehog. Mammals regenerate minimally, planaria regenerate whole body but are invertebrate lacking heart chamber complexi

Ref: Gilbert, Developmental Biology, 12th ed., Chapter 19: Zebrafish as model for heart, retina, and fin regeneration.

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