Skip to content
Login Register

#G-protein

8 public questions tagged with this topic.

Cell Signaling GPCR Pathways - I

Second messenger increased by Gαs signaling is

cAMP, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details
Cell Signaling GPCR Pathways - I

Pertussis toxin ADP-ribosylates

Pertussis toxin ADP-ribosylates Gαi, preventing the inhibitory G protein from interacting with receptors and thereby blocking its ability to inhibit adenylyl cyclase. The resulting loss of tonic inhibition elevates cAMP levels and contributes to the pathogenesis of whooping cough. The toxin has also become a valuable experimental tool for identifying Gi-coupled pathways.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details
Cell Signaling GPCR Pathways - I

β-adrenergic receptor signaling uses which G-protein?

Gs, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

View Details