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#follicle cells

2 public questions tagged with this topic.

Biochemistry

In Drosophila embryogenesis, the signal received from Gurken proteins by follicle cells results in posteriorization of t

Mechanistically, enzyme catalysis and lipid structure involves substrate affinity, transition state stabilization and phospholipid composition govern function. This validates Accumulation of maternal mRNAs because it reflects catalytic efficiency and membrane organization, a pattern repeatedly demonstrated in biochemistry research.

Ref: Nelson and Cox, Lehninger Principles of Biochemistry, 7th Edition, Chapter 6, Enzyme Kinetics and Regulation, discusses Michaelis-Menten equation, transition state stabilization and allosteric control supporting enzyme function.

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Drosophila -l

The follicle cells receiving Gurken signaling in Drosophila become:

During mid-oogenesis, oocyte nucleus migrates to dorsal-anterior corner secreting Gurken ligand. Nearby follicle cells expressing EGFR Torpedo bind Gurken, triggering Ras-Raf-MEK-ERK cascade and expression of dorsal follicle markers such as Fos, Broad-Complex and Keel. These cells produce dorsal eggshell appendages and dorsalize embryo indirectly by repressing Pipe sulfotransferase. Ventral follicle cells not receiving Gurken retain Pipe expression necessary for ventralizing Spätzle cleavage later. Therefore follicle population receiving Gurken signal adopts dorsalized fate, secreting dorsal p

Ref: Gilbert, Developmental Biology, 12th ed., Chapter 9: Gurken EGFR signaling dorsalizes follicle cells.

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