Which mitochondrial enzyme complex is involved in fatty acid oxidation?
Long-chain fatty acids activated to fatty acyl-CoA by acyl-CoA synthetase on the cytosolic face of endoplasmic reticulum and outer mitochondrial membrane cannot diffuse across the inner mitochondrial membrane, so a dedicated import shuttle is essential for matrix beta-oxidation. Carnitine palmitoyltransferase I, CPT I, localized to the outer membrane with catalytic site facing cytosol, transfers the acyl group to carnitine, forming acylcarnitine plus free CoA. Acylcarnitine is then shuttled across the inner membrane by the carnitine-acylcarnitine translocase, CACT, an antiporter exchanging acy
Ref: Berg et al., Biochemistry, 9th ed., Chapter 22: Fatty Acid Oxidation and Carnitine Shuttle.
