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#Drosophila development

2 public questions tagged with this topic.

Drosophila -ll

Expression of pair-rule genes occurs in:

After gap proteins establish regional information, pair-rule genes including even-skipped, fushi tarazu, hairy, runt translate graded inputs into periodic expression via combinatorial enhancer logic integrating Bicoid activation and Gap repression. At syncytial blastoderm each gene resolves into seven transverse stripes encircling embryo, corresponding to alternate parasegments. Uniform bands represent maternal genes, posterior domain gap genes. Seven-stripe configuration provides first metameric prepattern visualized by antibody staining, serving as landmarks that activate segment polarity ge

Ref: Gilbert, Developmental Biology, 12th ed., Chapter 9: Pair-rule genes - seven alternating stripes at blastoderm stage.

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Drosophila -ll

Maternal deficiency in torpedo results in embryos that are:

Torpedo encodes EGFR in follicle cells receiving Gurken ligand. Normally Gurken activates Torpedo dorsally repressing pipe transcription dorsally, restricting Pipe to ventral follicle cells. Deficiency in torpedo abolishes dorsal follicle fate markers mirror and Broad-Complex, causing all follicle cells to adopt ventral fate expressing Pipe uniformly. Classical experiments show torpedo and gurken mutants produce dorsalized embryos with fused dorsal appendages and absence of mesoderm because ventral protease cascade fails to become spatially restricted. Phenotype described as completely dorsali

Ref: Gilbert, Developmental Biology, 12th ed., Chapter 9: torpedo EGFR mutants produce dorsalized embryos lacking mesoderm and twist.

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