The main difference between domain and motif in protein structure is:
In biochemistry, enzyme catalysis and lipid structure dictates that substrate affinity, transition state stabilization and phospholipid composition govern function. Therefore Domain can remain stable, independent of the rest of the protein while motif ... is correct as it reflects catalytic efficiency and membrane organization, supported by mechanistic studies and conserved
Ref: Berg, Tymoczko, Gatto and Stryer, Biochemistry, 9th Edition, Chapter 13, Metabolism and Bioenergetics, covers glycolysis, citric acid cycle, oxidative phosphorylation and NADH-linked reactions detailing biochemical principles of cellular energy metabolism.
