The major and minor grooves of B-form DNA correspond to the following feature of A-form RNA
Mechanistically, nucleic acid structure and recombination involves hairpin formation, Holliday junction resolution and translation control ensure fidelity. This validates deep and shallow grooves because it matches molecular mechanisms, a pattern repeatedly demonstrated in molecular biology research.
Ref: Watson et al., Molecular Biology of the Gene, 7th Edition, Chapter 9, Transcription and RNA Processing, describes RNA hairpin formation, secondary structures and regulatory mechanisms controlling gene expression.
