Skip to content

#diseases

7 public questions tagged with this topic.

Trypanosoma causes

Trypanosoma brucei subspecies cause African sleeping sickness, transmitted by tsetse fly Glossina. Parasites live extracellularly in blood, lymph and cerebrospinal fluid, evading immunity through antigenic variation of variant surface glycoprotein coat continuously switching. Disease progression includes hemolymphatic stage with fever and lymphadenopathy, followed by meningoencephalitic stage disrupting sleep-wake cycle due to neuroinvasion. Plasmodium causes malaria, Vibrio cholera causes cholera, Mycobacterium causes tuberculosis. Distinct vector-borne life cycle and pathogenesis identifies

Ref: NCBI Bookshelf, Medical Microbiology: Trypanosoma Sleeping Sickness; Campbell Biology 12th ed., Chapter 28 Kinetoplastid Parasites

Hyperactive Wnt signaling is commonly seen in

Colon cancer, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

Which of the following diseases is NOT associated with protein misfolding?

Sickle cell anemia is the correct choice because it does not accurately describe or belong to the category addressed in this question. In the context of Protein Folding, the other options (Alzheimer’s disease, Huntington’s disease, and Cystic fibrosis) are all valid and well-established concepts. Sickle cell anemia is either unrelated to the topic, describes a different biological process, or represents a common misconception. Questions framed as 'which is NOT' require students to identify the exception among otherwise correct statements, demanding comprehensive knowledge of the topic rath

Ref: Lehninger Principles of Biochemistry, Nelson & Cox, 8th Ed., Ch. 4