Agglutination reactions are based on:
Agglutination reaction visual detection of antigen antibody crosslinking forming large lattices precipitating out of suspension forms basis rapid diagnostics usable at bedside without sophisticated equipment. Mechanism relies on multivalent antigen expressed repetitively on particulate carriers like erythrocytes expressing ABO antigens A trisaccharide with terminal N-acetylgalactosamine, Rh D polypeptide 12 transmembrane helices, bacteria displaying O polysaccharide lipopolysaccharide, or inert latex beads coated with purified recombinant protein, crosslinked by multivalent antibodies. IgM pen
Ref: Kuby Immunology Heidelberger-Kendall agglutination lattice IgM; CDC blood typing direct indirect agglutination equivalence.
