Which of the following is NOT a feature of a determined cell?
Determined cells exhibit stable, self-sustaining commitment enforced by profound molecular mechanisms including DNA methylation, Polycomb-mediated repression of alternative lineage genes, histone modifications and positive autoregulatory transcription factor loops that maintain expression without ongoing external signals. This epigenetic lockdown allows autonomous differentiation even when placed in ectopic environments exposing them to contradictory cues that would normally redirect naive cells. Concept of reversible fate contradicts determination definition; labile reversal applies to specif
Ref: Gilbert, Developmental Biology, 12th ed., Chapter 5: Properties of Determined Cells and Stability.
