#degradation

Sea Urchin -ll

Disheveled prevents degradation of:

Disheveled (Dsh) is key intracellular transducer of Wnt signaling vegetally localized in sea urchin egg cortex during oogenesis. It binds and inhibits Axin-GSK-3β-APC destruction complex responsible for phosphorylating β-catenin at N-terminus and marking it for ubiquitin-proteasome degradation. By preventing phosphorylation, Disheveled stabilizes β-catenin allowing cytoplasmic accumulation and subsequent nuclear import in vegetal blastomeres. Nuclear β-catenin partners with TCF/LEF to activate endomesodermal gene regulatory network and Pmar1. Hence Disheveled action preserves β-catenin, establ

Ref: Weitzel et al., Development 2004, Disheveled localization; Gilbert Chapter 8: Wnt/β-catenin regulation by Dsh.

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Cancer

HIF-1α is degraded under normoxia due to action of

PHD and VHL, is consistent with established principles of cell signaling, receptor pharmacology and cellular regulation. Experimental measurements of binding parameters, genetic loss-of-function studies and pharmacological interventions all converge on the same interpretation. Related options address neighboring concepts but do not satisfy the precise criterion stated in the question.

Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)

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Phytohormone ALL PYQS

JA signaling involves degradation of:

That points to C: JAZ. Compared with the other options, JAZ is the one that correctly describes the Phytohormone ALL concept. The wrong ones are A) AUX/IAA; B) DELLA; D) EBF1. If you’re stuck, eliminate anything that contradicts a basic fact you already know for this topic.

Ref: Best CSIR NET Plant Physiology books: Master Unit 6 with Taiz & Zeiger and Salisbury & Ross. Crack Part C experimental questions with top textbooks.

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cryptochrome

CRY2 protein is preferentially degraded under:

Go with C — Blue light. Under cryptochrome, this is the standard explanation you’d use in class: it names the real driver or definition, while the rest are nearby but wrong. Not these: A) Red light; B) Darkness; D) Far-red light. When two options sound similar, choose the one that matches the textbook definition most tightly.

Ref: Best CSIR NET Plant Physiology books: Master Unit 6 with Taiz & Zeiger and Salisbury & Ross. Crack Part C experimental questions with top textbooks.

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