TLR9 recognizes
TLR9 resides in endolysosomes and detects unmethylated CpG DNA motifs that are common in bacterial and viral genomes but rare in vertebrate DNA. Engagement of TLR9 activates MyD88-dependent signaling that drives pro-inflammatory cytokine and type-I interferon production, contributing to both antimicrobial defense and the pathogenesis of certain autoimmune diseases. Careful
Ref: NCERT Biology Class 11–12 Alberts et al Molecular Biology of the Cell Lodish et al, Molecular Cell Biology Cooper & Hausman, The Cell Abbas et al., Cellular and Molecular Immunology (for immunology sections)
